Scaling Up: Recovering Costs to Enable Mission-Driven Library Publishing

This deposit contains the text and the slides of a presentation given at the second annual Library Publishing Forum, March 29, 2015, in Portland, OR.Of the 124 LPC members listed in the 2015 Library Publishing Directory, only eight organizations indicate that they receive any revenue from chargebacks to the authors, editors, faculty, departments, or organizations they serve. Michigan Publishing is not one of these, but by the time the 2016 Library Publishing Directory is published, it will be. Taking the emerging Michigan Publishing Services and the long-running Michigan Journals programs as case studies, this presentation makes the case that attempting to recover costs by charging for services provided allows library publishing initiatives to: * scale up sustainably, responding to faculty demand for new services and projects and providing better tools and infrastructure to their partners. * advertise services and recruit new offerings clearly and proactively, rather than scrambling to estimate costs for each new project or turning away projects due to insufficient capacity. * steward university resources--such as departmental funds, research funds, grants, etc.--well by leveraging existing skills and vendor relationships to meet faculty needs in an efficient and mutually beneficial way. We will share the cost model(s) that are emerging here at Michigan Publishing, along with a look under the hood at the challenges we have faced in developing this framework, including coordinating with the university’s central finance office, complying with federal regulations, and communicating these changes to our publishing partners. Finally, we will demonstrate that this is very much a work in progress by projecting where we hope this trajectory will take us in a few years’ time.http://deepblue.lib.umich.edu/bitstream/2027.42/111646/1/colmanwelzenbachScalingUp2015.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/111646/2/colmanwelzenbach-Scaling Up Slides2015.pdfDescription of colmanwelzenbachScalingUp2015.pdf : Rough text of the talkDescription of colmanwelzenbach-Scaling Up Slides2015.pdf : Slide

Non-Destructive Characterization of Peripheral Arteries using Intravascular Ultrasound

Peripheral Artery Disease (PAD) is the chronic obstruction of blood flow to the extremities caused by plaque buildup. Poor circulation results in exertional pain, numbness, and weakness, and in severe cases, can manifest critical conditions, including gangrene and limb loss. PAD affects approximately 8.5 million Americans and costs the United States $21 billion annually in direct medical expenses. High expenditures are attributed to operation and intervention failures resulting in frequent need for revascularization. Treatment of PAD typically involves lifestyle/diet adjustments, bypass surgery, or angioplasty/stenting. Unfortunately, repeated limb deformation during locomotion often results in adverse repair device-artery interactions, which hinder the long-term efficacy of endovascular therapies. Patient and lesion-specific device selection guided by computational modeling can help improve clinical outcomes, but these models rely heavily on accurately recorded three-dimensional arterial geometry and plaque composition. Intravascular ultrasound (IVUS) is a minimally invasive method of endovascular imaging that allows evaluation of the geometry and composition of the arterial wall, but its two-dimensional nature is often insufficient to capture complex three-dimensional plaques. We have developed a method of obtaining three-dimensional arterial geometry from two-dimensional IVUS images to build Computer-Aided Design models of calcified human femoropopliteal arteries. Our imaging method will allow for the characterization of calcium, necrotic core, fibrofatty, and fibrous tissue using IVUS. Correlation of IVUS images with conventional histology, micro-CT imaging, and clinical CTA data will help inform computational models.https://digitalcommons.unmc.edu/surp2021/1025/thumbnail.jp

Gridmapping the northern plains of Mars: Geomorphological, Radar and Water-Equivalent Hydrogen results from Arcadia Plantia

A project of mapping ice-related landforms was undertaken to understand the role of sub-surface ice in the northern plains. This work is the first continuous regional mapping from CTX (“ConTeXt Camera”, 6 m/pixel; Malin et al., 2007) imagery in Arcadia Planitia along a strip 300 km across stretching from 30°N to 80°N centred on the 170° West line of longitude. The distribution and morphotypes of these landforms were used to understand the permafrost cryolithology. The mantled and textured signatures occur almost ubiquitously between 35° N and 78° N and have a positive spatial correlation with inferred ice stability based on thermal modelling, neutron spectroscopy and radar data. The degradational features into the LDM (Latitude Dependent Mantle) include pits, scallops and 100 m polygons and provide supporting evidence for sub-surface ice and volatile loss between 35-70° N in Arcadia with the mantle between 70-78° N appearing much more intact. Pitted terrain appears to be much more pervasive in Arcadia than in Acidalia and Utopia suggesting that the Arcadia study area had more wide-spread near-surface sub-surface ice, and thus was more susceptible to pitting, or that the ice was less well-buried by sediments. Correlations with ice stability models suggest that lack of pits north of 65-70° N could indicate a relatively young age (~1Ma), however this could also be explained through regional variations in degradation rates. The deposition of the LDM is consistent with an airfall hypothesis however there appears to be substantial evidence for fluvial processes in southern Arcadia with older, underlying processes being equally dominant with the LDM and degradation thereof in shaping the landscape

kNN Classification of Epilepsy Brainwaves

Epilepsy is a disorder of the normal brain function by the existence of abnormal synchronous discharges in large groups of neurons in brain structures and it is estimated about 1% of the world’s population suffers from this disease [Tzallas et al., 2009]. It has been reported that the brainwave of Epilepsy patient mostly in sharp, spike and complex wave pattern [Tzallas et al., 2009]. In addition, Epilepsy brainwaves pattern lies in wide variety of Electroencephalogram (EEG) signals in formed of low-amplitude and polyspikes activity [Vargas et al., 2011]. Generally, this disease was examined through the brainwaves or EEG signals by clinical neurulogists. An EEG is a device to record the brainwaves in term of electrical activity from the brain. Brain patterns from wave shapes that are commonly sinusoidal and measured from peak to peak that range from 0.5 μV to 100 μV in amplitude. Moreover, the brainwaves have been categorized into four frequency bands, Beta (>13 Hz), Alpha (8-13 Hz), Theta (4-8 Hz) and Delta (0.5-4 Hz). All the frequency bands will be used to characterize the Epilepsy brainwave in terms of amplitude (voltage) and frequency [Mustafa et al., 2013]. The Epilepsy brainwaves were downloaded from http://www.vis.caltech.edu/~rodri/data.htm of Fp1 and Fp2 channels which is from rats. The brainwaves consists Epilepsy and non-Epilepsy samples. Then, the brainwaves were pre-processed to remove artefact (noise). Various methods had been introduced to detect spike-wave discharge in Epilepsy patient brainwave. Brainwave is nonstationary signal, therefore, time-frequency analysis is appropriate methods to analyse the signals[Tzallas et al., 2009, Vargas et al., 2011]. One of the most popular time-frequency analyses is ShortTime Fourier Transform (STFT). After the brainwaves were pre-processed, STFT was employed to the clean brainwaves. The STFT spectrogram was generated for four frequency bands of the samples

Complete Genome Sequence of the Aerobic CO-Oxidizing Thermophile Thermomicrobium roseum

In order to enrich the phylogenetic diversity represented in the available sequenced bacterial genomes and as part of an “Assembling the Tree of Life” project, we determined the genome sequence of Thermomicrobium roseum DSM 5159. T. roseum DSM 5159 is a red-pigmented, rod-shaped, Gram-negative extreme thermophile isolated from a hot spring that possesses both an atypical cell wall composition and an unusual cell membrane that is composed entirely of long-chain 1,2-diols. Its genome is composed of two circular DNA elements, one of 2,006,217 bp (referred to as the chromosome) and one of 919,596 bp (referred to as the megaplasmid). Strikingly, though few standard housekeeping genes are found on the megaplasmid, it does encode a complete system for chemotaxis including both chemosensory components and an entire flagellar apparatus. This is the first known example of a complete flagellar system being encoded on a plasmid and suggests a straightforward means for lateral transfer of flagellum-based motility. Phylogenomic analyses support the recent rRNA-based analyses that led to T. roseum being removed from the phylum Thermomicrobia and assigned to the phylum Chloroflexi. Because T. roseum is a deep-branching member of this phylum, analysis of its genome provides insights into the evolution of the Chloroflexi. In addition, even though this species is not photosynthetic, analysis of the genome provides some insight into the origins of photosynthesis in the Chloroflexi. Metabolic pathway reconstructions and experimental studies revealed new aspects of the biology of this species. For example, we present evidence that T. roseum oxidizes CO aerobically, making it the first thermophile known to do so. In addition, we propose that glycosylation of its carotenoids plays a crucial role in the adaptation of the cell membrane to this bacterium's thermophilic lifestyle. Analyses of published metagenomic sequences from two hot springs similar to the one from which this strain was isolated, show that close relatives of T. roseum DSM 5159 are present but have some key differences from the strain sequenced

Low Concentrations of Silver Nanoparticles in Biosolids Cause Adverse Ecosystem Responses under Realistic Field Scenario

A large fraction of engineered nanomaterials in consumer and commercial products will reach natural ecosystems. To date, research on the biological impacts of environmental nanomaterial exposures has largely focused on high-concentration exposures in mechanistic lab studies with single strains of model organisms. These results are difficult to extrapolate to ecosystems, where exposures will likely be at low-concentrations and which are inhabited by a diversity of organisms. Here we show adverse responses of plants and microorganisms in a replicated long-term terrestrial mesocosm field experiment following a single low dose of silver nanoparticles (0.14 mg Ag kg−1 soil) applied via a likely route of exposure, sewage biosolid application. While total aboveground plant biomass did not differ between treatments receiving biosolids, one plant species, Microstegium vimeneum, had 32 % less biomass in the Slurry+AgNP treatment relative to the Slurry only treatment. Microorganisms were also affected by AgNP treatment, which gave a significantly different community composition of bacteria in the Slurry+AgNPs as opposed to the Slurry treatment one day after addition as analyzed by T-RFLP analysis of 16S-rRNA genes. After eight days, N2O flux was 4.5 fold higher in the Slurry+AgNPs treatment than the Slurry treatment. After fifty days, community composition and N2O flux of the Slurry+AgNPs treatment converged with the Slurry. However, the soil microbial extracellular enzymes leucine amino peptidase and phosphatase had 52 and 27% lower activities, respectively, while microbial biomass was 35% lower than the Slurry. We also show that the magnitude of these responses was in all cases as large as or larger than the positive control, AgNO3, added at 4-fold the Ag concentration of the silver nanoparticles